ReviewCureus2025
Efficacy and Safety of Tapinarof for Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of tapinarof in atopic dermatitis: a frequentist and bayesian meta-analysis of randomized controlled trials.Inflammopharmacology · 2026Pooled it
- Three-Year Efficacy and Safety of Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Long-Term Extension (ADjoin).Dermatology and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis evaluated the efficacy and safety of 1% tapinarof cream once daily (QD) in patients with mild-to-severe atopic dermatitis (AD). Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Embase, Cochrane, and ClinicalTrials.gov databases for placebo-controlled, randomized trials up to March 2025. Four studies reporting five randomized trials involving a total of 1191 patients met the inclusion criteria. Primary endpoints included Investigator Global Assessment (IGA) success and achievement of Eczema Area and Severity Index 75% (EASI-75) response. Secondary outcomes included improvement in Peak Pruritus Numeric Rating Scale (PP-NRS) scores and incidence of adverse events (AEs). After eight weeks, patients receiving tapinarof 1% QD were associated with significantly higher IGA success rates (risk ratio (RR) = 3.03, 95% CI: 1.94-4.74, p = 0.002), EASI-75 response rates (RR = 2.99, 95% CI: 1.94-4.60, p = 0.002), and clinically meaningful improvement in PP-NRS scores of ≥4 points (RR = 1.58, 95% CI: 1.10-2.26, p = 0.03) compared to placebo. Tapinarof also showed a modest but statistically significant increase in the overall incidence of adverse events (AEs) (RR = 1.39, 95% CI: 1.02-1.90, p = 0.04), while the rate of serious AEs was not significantly different between groups (RR = 1.98, 95% CI: 0.36-24.69, p = 0.31). In conclusion, tapinarof cream 1% QD demonstrated significant efficacy in treating mild-to-severe AD, with improvements in clinical signs and pruritus. It was generally well tolerated, supporting its use as a non-steroidal topical therapy in this patient population. Protocol registered in International Prospective Register of Systematic Reviews (PROSPERO) (CRD420251000807), with risk of bias assessed using the Cochrane risk-of-bias (RoB 2) tool and certainty of evidence appraised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.