ReviewCureus2025
Pediatric Applications of Digital Therapeutics: Clinical Evidence and Implementation Landscape.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multimodal Digital Therapeutics Enhanced by Task Design and AI for Attention-Deficit/Hyperactivity Disorder Core Symptoms and Executive Functions in Children and Adolescents: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Binocular Vision Anomalies: An Update on Prevalence, Impact, Technological and Treatment Developments and Current Challenges.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Computer-assisted cognitive training in children with developmental disorders: a scoping review of available tools, clinical targets, and evidence gaps.Frontiers in pediatrics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Digital therapeutics (DTx) are evidence-based software interventions designed to prevent, manage, or treat medical conditions through validated therapeutic mechanisms of action. They are emerging as a transformative paradigm in pediatric healthcare, where accessibility, engagement, and personalization are particularly critical. This review examines the landscape of prescription digital therapeutics for children and adolescents, focusing on current applications, regulatory considerations, implementation challenges, and future innovations. Although only a limited number of prescription digital therapeutics have been formally authorized for pediatric use, early examples demonstrate feasibility and therapeutic benefit for conditions such as attention-deficit/hyperactivity disorder (ADHD) and amblyopia. Beyond these, research is rapidly expanding into a broader set of conditions, including autism spectrum disorders, anxiety, substance use prevention, and management of chronic illnesses, highlighting the potential of digital therapeutics to complement traditional treatment approaches in specific contexts. Despite this promise, several barriers to implementation remain, with access constrained by the digital divide, socioeconomic disparities, and variability in insurance reimbursement. Additional challenges include ensuring developmental appropriateness, addressing privacy and safety concerns specific to children, and creating sustainable clinical integration pathways. Looking ahead, emerging technologies such as artificial intelligence-driven personalization, immersive virtual and augmented reality environments, and integration with wearable devices offer opportunities to overcome current limitations. Pediatric digital therapeutics hold promise as tools that may advance precision medicine, though current evidence is limited mainly to a few conditions, such as ADHD and amblyopia. With the potential to deliver scalable, cost-effective, and engaging interventions that expand access to high-quality care for children worldwide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.