ArticleCureus2025
Clozapine Toxicity Following Aortic Valve Replacement in the Context of Pleural Effusion: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Clozapine toxicity is a potentially life-threatening condition that can result from altered drug metabolism, leading to elevated serum levels and systemic adverse effects. Although it is commonly associated with infections and metabolic changes, its occurrence in the setting of recent cardiac surgery and pleural effusion is not well documented. We present the case of a 42-year-old female with a history of schizoaffective disorder, bipolar disorder, and recent mechanical aortic valve replacement, who developed worsening dyspnea and postoperative pleural effusions. Her hospital course was complicated by supratherapeutic clozapine levels, recurrent pleural effusions requiring thoracentesis and chest tube placement, and anticoagulation management challenges due to the mechanical valve. Despite diuresis and pleural drainage, her symptoms persisted, leading to clozapine discontinuation. After dose adjustments and close monitoring, her respiratory status improved, and serum clozapine levels returned to normal.
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