ReviewCureus2025
Acute Salicylate Toxicity: A Narrative Review for Emergency Clinicians.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Attenuation of imidacloprid deleterious effect on hepatic and neural tissues via acetylsalicylic acid: targeting HMGB1/caspase-3 axis and inflammatory pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Seizures from Chronic Salicylate Intoxication Following Household Exposure to Incense Fumes.The American journal of case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute salicylate toxicity is a major source of morbidity and mortality. A multitude of medications, including over-the-counter therapies and topical treatments, contain salicylates. In overdose, they result in uncoupling of oxidative phosphorylation, inhibition of citric acid dehydrogenases, increased keto-acid production, and decreased ATP production, leading to a progression of signs and symptoms. Patients may develop respiratory alkalosis and an anion gap metabolic acidosis. Patients present with a range of symptoms, including nausea, vomiting, diarrhea, tinnitus, altered mental status, agitation, seizures, pulmonary edema, and coma. Acute treatment includes gastrointestinal decontamination, serum alkalinization, and fluid resuscitation. Hemodialysis is necessary in cases with severely high serum salicylate concentrations, hypoxia, altered mental status, and significant acid-base disorders. This review highlights the pearls and pitfalls of acute salicylate toxicity, including presentation, diagnosis, and management in the emergency department based on current evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.