Evidence map›Paper›PMID 41049824›Full record

ReviewAsian journal of urology2025

Kidney-sparing approach for upper tract urothelial carcinoma: An update on current evidence.

Ivan Ching Ho Ko, Chris Ho Ming Wong, David Ka Wai Leung, Alex Qin-Yang Liu, Kevin Cheuk Kin Cheng, Brian Wai Hei Siu, Steffi Kar Kei Yuen, Nikhil Vasdev, Keiichiro Mori, Karl H Tully and 3 more

Abstract readReview
In one paragraph

Review in Asian journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ivan Ching Ho KoS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Chris Ho Ming WongS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
David Ka Wai LeungS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Alex Qin-Yang LiuS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Kevin Cheuk Kin ChengS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Brian Wai Hei SiuS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Steffi Kar Kei YuenS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Nikhil VasdevDepartment of Urology, Lister Hospital, Stevenage, UK.
Keiichiro MoriDepartment of Urology, Jikei University School of Medicine, Tokyo, Japan.
Karl H TullyDepartment of Urology and Neurourology, Marien Hospital Herne, Ruhr-University, Bochum, Germany.
Dmitry EnikeevRabin Medical Center (Belenson, Hasharon), Petah Tikva, Israel.
Anthony Chi Fai NgS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Jeremy Yuen Chun TeohS.H Ho Urology Centre, Prince of Wales Hospital, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This article reviews the latest updates and outcomes of kidney-sparing surgery (KSS) in patients with upper tract urothelial carcinoma (UTUC). Methods: A comprehensive literature search was performed using the PubMed and Embase databases to identify related English-language studies published within the last 10 years. Key search words included "upper urinary tract tumour/cancer/carcinoma", "kidney-sparing surgery or approach", "endoscopic treatment for upper tract tumour/cancer/carcinoma", "topical instillation in the upper urinary tract", and "urinary marker for urothelial carcinoma". References within the identified literature were explored and evaluated for relevance. Results: KSS is recommended for both low-risk and selected high-risk UTUC with imperative indications such as solitary kidney. Studies have shown comparable oncological outcomes after KSS including endoscopic ablation, segmental ureterectomy, and topical instillation of novel agents when compared to radical nephroureterectomy in well-selected cases. The development of novel diagnostic tools and risk-stratifying models allows optimal case selection for KSS without compromising oncological outcomes. Conclusion: Kidney-sparing approach for UTUC is an evolving and promising area in urologic oncology, driven by advances in technology, better diagnostic tools, and novel therapeutic agents. Our article provides a comprehensive review of the latest advancements and clinical recommendations. While current evidence is mainly based on retrospective studies, prospective trials are required to address important but unanswered clinical questions in this field.

Indexed as

Endoscopic treatmentKidney-sparing approachSegmental ureterectomyTopical instillation in upper tractUpper tract urothelial carcinoma

Identifiers

PMID41049824
PMCPMC12490676

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.