ArticleEvolution letters2025
Pleiotropy increases with gene age in six model multicellular eukaryotes.
Article in Evolution letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Signatures of selection in pleiotropic genes involved in insect neuronal and immune systems.G3 (Bethesda, Md.) · 2026Article
- Signatures of selection in pleiotropic genes involved in insect neuronal and immune systems.bioRxiv : the preprint server for biology · 2026Article
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2 authors.
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Abstract
Fundamental traits of genes, including function, length, and Guanine-Cytosine (GC) content, all vary with gene age. Pleiotropy, where a single gene affects multiple traits, arises through selection for novel traits and is expected to be removed from the genome through subfunctionalization following duplication events. It is unclear, however, how these opposing forces shape the prevalence of pleiotropy through time. We hypothesized that the prevalence of pleiotropy would be lowest in young genes, peak in middle-aged genes, and then either decrease to a middling level in ancient genes or stay near the middle-aged peak, depending on the balance between exaptation and subfunctionalization. To address this question, we have calculated gene age and pleiotropic status for several model multicellular eukaryotes, including
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