Evidence map›Paper›PMID 41049743›Full record

ArticleActa pharmaceutica Sinica. B2025

Discovery of powerful multifaceted antioxidant for combating oxidative stress associated with neurodegenerative disorders.

Juhee Khan, Prabir Kumar Gharai, Shubham Garg, Sanju Gupta, Mohammad Umar Arshi, Rathnam Mallesh, Surajit Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juhee KhanOrganic and Medicinal Chemistry and Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
Prabir Kumar GharaiOrganic and Medicinal Chemistry and Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
Shubham GargDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Rajasthan 342037, India.
Sanju GuptaDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Rajasthan 342037, India.
Mohammad Umar ArshiDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Rajasthan 342037, India.
Rathnam MalleshOrganic and Medicinal Chemistry and Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
Surajit GhoshOrganic and Medicinal Chemistry and Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amidst the tangled web of neurons, antioxidants stand as silent sentinels, shielding the delicate threads from the raging storm of oxidative stress in the realm of neurological affliction. Herein, we showcased an innovative design strategy to develop a novel powerful antioxidant small molecule (AOX), designed with the synergistic integration of EGCG (epigallocatechin gallate), gallic acid, and coupled with the metal-chelating capabilities of 8-hydroxy quinoline functional moieties that exhibit multifunctional activity in combating oxidative stress

Indexed as

AntioxidantHydrogen peroxideIschemic strokeNeuroprotectionNrf2/ARE pathwayOxidative stressPolyphenoltBCCAO

Identifiers

PMID41049743
PMCPMC12491703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.