Evidence map›Paper›PMID 41049697›Full record

ArticlePaediatrics & child health2025

Short and long-term outcomes in neonatal hypoxic-ischemic encephalopathy treated with hypothermia and vasoactive medications.

Telford Yeung, Ali Al Sawai, Sharifa Habib, Diane Wilson, Vann Chau, Bonny Jasani, Amr El Shahed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatrics & child health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Telford YeungSection of Newborn Critical Care, Department of Pediatrics, University of Calgary, Canada.
Ali Al SawaiKhoula Hospital, Division of Neonatology, Muscat, Oman.
Sharifa HabibDivision of Neonatology, The Hospital for Sick Children, Toronto, Canada.
Diane WilsonDivision of Neonatology, The Hospital for Sick Children, Toronto, Canada.
Vann ChauDivision of Neurology, The Hospital for Sick Children, Toronto, Canada.
Bonny JasaniDivision of Neonatology, The Hospital for Sick Children, Toronto, Canada.
Amr El ShahedDivision of Neonatology, The Hospital for Sick Children, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hemodynamic instability in neonatal hypoxic-ischemic encephalopathy (HIE) can contribute to brain injury but long-term neurodevelopmental data is limited. Our objective was to compare the effect of hemodynamic instability requiring vasoactive support on radiologic brain injury and neurodevelopmental outcomes in HIE with therapeutic hypothermia (TH). Methods: This retrospective cohort study compared infants with HIE post-TH who did not require (Group I) versus those who required vasoactive medications (Group II). The association between hemodynamic instability and MRI brain injury or Bayley Scales of Infant Development III (BSID-III) was evaluated by logistic regression. Results: Among 185 infants, group II had higher adjusted odds of moderate-severe grey matter injury [odds ratio 5.54; 95% confidence interval 1.70 - 18.05; p < 0.001] than group I, with no differences in adjusted 18-24-month BSID-III scores. Conclusion: Hemodynamic instability requiring vasoactive support in HIE with TH was associated with higher odds of radiologic brain injury but no difference in neurodevelopmental outcomes.

Indexed as

Brain injuryHemodynamic instabilityHypoxic-ischemic encephalopathyNeonateNeurodevelopmental outcome

Identifiers

PMID41049697
PMCPMC12495522

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.