Evidence map›Paper›PMID 41049676›Full record

ArticleJSES international2025

Higher postoperative gabapentin doses are associated with pulmonary complications after total shoulder arthroplasty.

Julian Wier, Cory K Mayfield, Kevin C Liu, Eric H Lin, Cailan L Feingold, Alexander E Weber, Seth C Gamradt, Joseph N Liu, Frank A Petrigliano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JSES international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julian WierDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Cory K MayfieldDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Kevin C LiuDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Eric H LinDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Cailan L FeingoldDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Alexander E WeberDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Seth C GamradtDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Joseph N LiuDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
Frank A PetriglianoDepartment of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gabapentinoids are increasingly being used as adjunctive analgesic medications after total shoulder arthroplasty (TSA). However, data suggest that when used in conjunction with opioids, gabapentinoids may induce sedation and possibly potentiate respiratory depression. The aim of this study was to evaluate the impact of gabapentin postoperative pulmonary complications and total opioid utilization after primary TSA. Methods: Patients who underwent primary, elective anatomic and reverse TSA from January 1, 2016, to December 31, 2020, were identified using the Premier Healthcare Database. The cumulative postoperative day 1 gabapentin exposure was calculated and divided into four groups: ("Control Dose": 0 mg, "Low Dose": 1-300 mg, "Moderate Dose": 301-900 mg, and "High Dose" >900 mg) based on distribution and commonly used inpatient dosing regimens. Multivariable models were conducted to evaluate the effect of gabapentin doses compared to none using the adjusted odds ratio (aOR) of pulmonary complications. Average daily morphine milligram equivalents (MMEs) were evaluated between groups. Results: A total of 86,137 patients who underwent TSA were identified; of these, 62,621 (72.70%) patients comprised the Control cohort, while 12,051 (13.99%) were categorized into the Low Dose; 9,465 (10.99%) into the Moderate Dose; and 2,000 (2.32%) into the High Dose cohort. Compared to the patients in the Control cohort, those in the Low (aOR: 1.15, 95% confidence interval [CI]: 1.02-1.30), Moderate (aOR: 1.17, 95% CI: 1.02-1.33), and High Dose (aOR: 1.45, 95% CI: 1.15-1.82) had increased odds of pulmonary complications. Average daily MME was 46.21 ± 100.98; 40.35 ± 63.57; 42.70 ± 54.10; and 49.15 ± 68.72 milligrams in the Control, Low, Moderate, and High Dose cohorts, respectively. Conclusion: Exposure to gabapentin during the perioperative period after TSA is independently associated with an increased risk of postoperative pulmonary complications. We observed no clinically significant differences in overall MME intake.

Indexed as

Anatomic total shoulder arthroplastyDatabaseGabapentinoidsPain controlPulmonary complicationsReverse total shoulder arthroplasty

Identifiers

PMID41049676
PMCPMC12490609

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.