ArticleJSES international2025
Impact of aging and estrogen deficiency on extracellular matrix-related gene expression in rotator cuff tendons: in vitro and in vivo rat model.
Article in JSES international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Tsukubacyclinone, a novel angucyclinone compound with anti-inflammatory activity in synovial cell line SW982, produced by Streptomyces sp. K21-0141.The Journal of antibiotics · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Injuries to the rotator cuff, including the supraspinatus, infraspinatus, subscapularis, and teres minor tendons, can cause significant pain and loss of function. Aging and postmenopause detrimentally affect the extracellular matrix (ECM) of these tendons, accelerating their degeneration. This study aimed to investigate the effects of aging and estrogen deficiency on the ECM-related gene expression of rotator cuff tendons. Methods: Female Wistar rats aged 12, 24, and 48 weeks were used to assess ECM-related gene expression in tendon insertions from the supraspinatus and infraspinatus tendons. Estrogen deficiency was modeled in female Wistar rats by performing bilateral ovariectomy (OVX), and a sham-operated group was used as the control group. Quantitative reverse-transcription polymerase chain reaction (qPCR) and RNA-sequencing (RNA-Seq) analyses were performed on harvested rotator cuff tissues 8 weeks postoperatively. Primary cells derived from these tissues were cultured and exposed to 17β-estradiol at various concentrations (0, 1, and 10 nM) for different durations (3, 6, and 24 hours), and their responses were analyzed using qPCR. Results: Conclusion: Aging was associated with reduced expression of
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