Prognostic significance and therapeutic implications of redox metabolism-related genes in head and neck squamous cell carcinoma.

Lina Yang, Jingyu Hai, Jiayi Liu, Shaohua Shen, Lin Su, Juan Sun

Abstract read

In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Lina YangDepartment of Otolaryngology, Head and Neck Surgery, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China.

Jingyu HaiDepartment of Otolaryngology, Head and Neck Surgery, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China.

Jiayi LiuDepartment of Otolaryngology, Head and Neck Surgery, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China.

Shaohua ShenDepartment of Chinese Traditional Medicine Department, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China.

Lin SuDepartment of Otolaryngology, Head and Neck Surgery, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China.

Juan SunDepartment of Otolaryngology, Head and Neck Surgery, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinomas (HNSC) are associated with alterations in redox metabolism. This study aims to identify differentially expressed genes (DEGs) related to redox metabolism in HNSC and assess their prognostic values. We utilized the limma package for identifying redox metabolism-related DEGs and performed univariate and multivariate Cox regression analyses to evaluate their prognostic significance. Gene set variation analysis (GSVA), immune cell infiltration analysis, and single-cell RNA sequencing were utilized to explore the relationships between gene expression and tumor processes. Chemotherapy sensitivity was assessed based on

Indexed as

Head and Neck NeoplasmsMembrane ProteinsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleOxidation-ReductionPrognosisBiomarkers, TumorMembrane Proteinschemotherapy sensitivityhead and neck squamous cell carcinomasimmune cell infiltrationsredox metabolismtumor microenvironment

Identifiers

PMID41049606

DOI10.3389/ebm.2025.10623

PMCPMC12492447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.