ArticleAmerican journal of preventive cardiology2025
Metabolic syndrome and the risk of incident heart failure: a prospective cohort study.
Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Targeting ceramides in metabolic syndrome: recent advances and therapeutic opportunities.Acta diabetologica · 2026Review
- Cardiometabolic health-frailty phenotypes and bidirectional transitions between atrial fibrillation and heart failure: multistate trajectories and proteomic signatures.The journal of nutrition, health & aging · 2026Article
- Study of the Relationship Between the Number of Metabolic Syndrome Components and Subclinical Cardiac Dysfunction: A Retrospective Analysis.Journal of clinical medicine · 2026Article
- Disulfidptosis in heart failure: an emerging mechanism awaiting exploration.Frontiers in cardiovascular medicine · 2026Review
- Association between the atherogenic index of plasma and major adverse cardiovascular events in individuals with metabolic syndrome: findings from the UK biobank.Cardiovascular diabetology · 2025Article
- Association Between High Serum Alanine Aminotransferase to High Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome among People Living with HIV on Dolutegravir-Based ART in South-Western Uganda.Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
6 authors.
Funding
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Abstract
aimPrevious studies have reported the link between metabolic syndrome (MetS) and multiple cardiovascular diseases. This study aimed to comprehensively investigate the role of MetS in the risk of developing HF.
methodsThis is a prospective cohort study based on UK Biobank. The components of MetS included increased blood pressure (P), central obesity (W), elevated blood glucose (G), reduced HDL cholesterol (H) and increased triglycerides (T); the cumulative burden of MetS components was defined as the sum of the presence of altered MetS components; and specific clusters of MetS components was defined as different combinations of the altered components. The outcome was incident heart failure. Cox proportional-hazards models were used to generate the estimates.
resultsOver a median follow-up for 13.2 years, 11,875 cases of incident HF occurred. As compared to individuals without altered component of MetS, the adjusted HRs gradually increased from 1.54, 1.64, 1.86, 2.18 to 2.62 across groups with 1-5 altered components, respectively. Increased blood pressure conferred a greater risk of HF than other components after adjustment, while increased triglycerides showed a protective effect, resulting in the highest risk observed in the clusters of PGHW (adjusted HR = 3.17, 95 % CI = 2.70-3.72), followed by PGHTW, PGW, PGH, and PGTW. These observed associations were almost stronger in younger adults than older participants, or in females than males.
conclusionCumulative burden of MetS was associated with higher incidence of HF, while which varied by different clusters.
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