Evidence map›Paper›PMID 41049496›Full record

ArticleFrontiers in physiology2025

Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation.

Auberi Henry, Laetitia Vanalderwiert, Floriane Oszust, Amandine Wahart, Daniel A Carvajal Berrio, Eva M Brauchle, Katja Schenke-Layland, Juergen Brinckmann, Heiko Steenbock, Laurent Debelle and 12 more

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Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Auberi Henry *UMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Laetitia Vanalderwiert *UMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Floriane OszustUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Amandine WahartUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Daniel A Carvajal BerrioInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.
Eva M BrauchleInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.
Katja Schenke-LaylandInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.
Juergen BrinckmannDepartment of Dermatology and Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany.
Heiko SteenbockDepartment of Dermatology and Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany.
Laurent DebelleUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Isabelle SixResearch Unit 7517, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications (MP3CV), University of Picardie Jules Verne, Amiens, France.
Gilles FauryUniversity of Grenoble Alpes, INSERM, CHU Grenoble Alpes, Grenoble, France.
Stéphane JaissonUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Philippe GilleryUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Vincent DurlarchUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Hervé SarteletUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Pascal MauriceUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Amar BennasrouneUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Laurent MartinyUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Laurent DucaUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Béatrice RomierUMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Sébastien Blaise *UMR CNRS 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic patients experience a significant reduction in life expectancy, primarily due to early cardiovascular complications. A key feature is the premature degradation of elastic fibers (EFs), contributing to vascular stiffness. Objective: This study evaluates the capacity of two antihypertensive agents, minoxidil (a KATP channel opener) and nebivolol (a β-blocker with KATP activity), to restore EF homeostasis and arterial elasticity in diabetic mice. Methods: Mice are treated with two antihypertensive agents: minoxidil (an ATP-sensitive potassium (KATP) channel opener) or nebivolol (a β-blocker also active on KATP channels). The degree of wear and functionality of EF are assessed after these treatments. We complement this analysis by identifying molecular actors from smooth muscle cell cultures. Results: Our data show that by applying these antihypertensive agents in cultured vascular smooth muscle cells Conclusion: Minoxidil and nebivolol restore EF integrity and limit vascular aging in diabetic mice via K+ channel opening and FOXO1 repression. These findings highlight potassium channel-FOXO1 signaling as a therapeutic axis to counteract diabetic vascular complications.

Indexed as

agingdiabeteselastogenesiselastolysisFOXO1potassium channel

Identifiers

PMID41049496
PMCPMC12488662

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.