Evidence map›Paper›PMID 41049487›Full record

ArticleFrontiers in physiology2025

Human red blood cell ATP content and export under hypoxic and/or isocapnic storage conditions.

Youwei Chen, Cole Darrow, Aidan Murray, Thomas Wise, Zhong Lucas Li, Nisha Srivastava, Hongmei Zhu, Ian J Welsby, Tatsuro Yoshida, Tim J McMahon

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Youwei ChenDepartment of Medicine, Duke University Health System, Durham, NC, United States.
Cole Darrow *Department of Medicine, Duke University Health System, Durham, NC, United States.
Aidan Murray *Department of Medicine, Duke University Health System, Durham, NC, United States.
Thomas Wise *Department of Medicine, Duke University Health System, Durham, NC, United States.
Zhong Lucas Li *Department of Medicine, Duke University Health System, Durham, NC, United States.
Nisha Srivastava *Department of Medicine, Duke University Health System, Durham, NC, United States.
Hongmei Zhu *Department of Medicine, Duke University Health System, Durham, NC, United States.
Ian J WelsbyDepartment of Medicine, Duke University Health System, Durham, NC, United States.
Tatsuro YoshidaHemanext, LLC, Lexington, MA, United States.
Tim J McMahonDepartment of Medicine, Duke University Health System, Durham, NC, United States.

Funding

Red blood cell ATP export and transfusion in sepsisR01HL161071 · NHLBI · DUKE UNIVERSITY · PI Allan Doctor, TIMOTHY J MCMAHON · 2023 to 2026
$2.7M
BLRD VA I01 BX003478NHLBI NIH HHS R01 HL161071
6 · The paper itself

Abstract

Introduction: In some diseases driving or associated with anemia, red blood cell (RBC) transfusion conveys limited benefit, and only when the anemia is severe. The banking of RBCs alters key molecules and functions. Among these changes during blood banking, depletion of the allosteric effector 2,3-BPG (biphosphoglycerate) takes place in the first two to 3 weeks, while ATP depletion only becomes prominent in the fifth or sixth (i.e., final) weeks of storage. One approach to testing the significance of these changes is to test the effects Methods: We performed a parallel study of conventional RBCs, hypoxically stored (Hemanext) RBCs ("HN-Std RBCs"), and CO Results and discussion: Standard hypoxic RBC storage boosted RBC ATP content, peaking in mid-storage. The time course of P

Indexed as

biphosphoglycerate (BPG)blood flowerythrocyteoxygen bindingtransfusion

Identifiers

PMID41049487
PMCPMC12488716

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.