Evidence map›Paper›PMID 41049466›Full record

ArticleJournal of optical microsystems2024

Compact scattering-based light sheet microscopy probe using a custom miniature objective lens.

Jingwei Zhao, Yongjun Kim, Momoka Sugimura, Kenneth Marcelino, Rafael Romero, Brooke Liang, Michelle Khan, Eric Yang, Dongkyun Kang

Abstract read
In one paragraph

Article in Journal of optical microsystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingwei ZhaoUniversity of Arizona, James C. Wyant College of Optical Sciences, Tucson, Arizona, USA, 85721.
Yongjun KimUniversity of Arizona, Department of Biomedical Engineering, Tucson, Arizona, USA, 85721.
Momoka SugimuraUniversity of Arizona, James C. Wyant College of Optical Sciences, Tucson, Arizona, USA, 85721.
Kenneth MarcelinoUniversity of Arizona, James C. Wyant College of Optical Sciences, Tucson, Arizona, USA, 85721.
Rafael RomeroUniversity of Arizona, Department of Biomedical Engineering, Tucson, Arizona, USA, 85721.
Brooke LiangStanford University School of Medicine, Department of Pathology, Stanford, California, USA, 94305.
Michelle KhanStanford University School of Medicine, Department of Obstetrics and Gynecology, Stanford, California, USA, 94305.
Eric YangStanford University School of Medicine, Department of Pathology, Stanford, California, USA, 94305.
Dongkyun KangUniversity of Arizona, James C. Wyant College of Optical Sciences, Tucson, Arizona, USA, 85721.

Funding

Low-Cost, Handheld Light Sheet Microscope for Guiding Anal Cancer DiagnosisR21EB030079 · NIBIB · UNIVERSITY OF ARIZONA · PI KANG, DONGKYUN, YANG, ERIC · 2021 to 2023
$543k
NIBIB NIH HHS R21 EB030079
6 · The paper itself

Abstract

We have developed a compact scattering-based light sheet microscopy (sLSM) probe capable of imaging unstained tissues with cellular resolution. In the compact sLSM probe, a custom miniature objective lens was developed to achieve a high lateral resolution, large field of view (FOV), and small field curvature. The measured resolution of the custom objective was 1.65-1.97 μm across the FOV of ± 1.0 mm. The compact probe had dimensions of 4 cm in width and height, and 10 cm in length. The compact sLSM probe achieved an axial resolution better than 5.6 μm over a depth range of 206.2 μm, and a lateral resolution of 1.9 μm. Preliminary results showed that the compact sLSM probe could visualize cellular details of fixed human anal epithelial tissues in a similar manner to a bench LSM device using off-the-shelf objective lenses.

Indexed as

compact microscopecustom objective lensintrinsic scatteringlight sheet microscopyminiature objective lensunstained tissue imaging

Identifiers

PMID41049466
PMCPMC12490782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.