Evidence map›Paper›PMID 41049444›Full record

ArticleInternational journal of medical sciences2025

Tetrahydrocurcumin Protects Microglial Cells Against

Hui-Wen Lin, Tzu-Chun Chen, Inga Wang, Jui-Hsuan Yeh, Shang-Chun Tsou, Lee Sun, Shih-Chi Chung, Chen-Ju Chuang, Yuan-Yen Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui-Wen LinInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Tzu-Chun ChenInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Inga WangRehabilitation Sciences & Technology, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
Jui-Hsuan YehInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Shang-Chun TsouDepartment of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, and Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Lee SunDepartment of Optometry, Asia University, Taichung 413, Taiwan.
Shih-Chi ChungDepartment of Nursing, Chung Shan Medical University, Taichung, 40201, Taiwan.
Chen-Ju ChuangEmergency department, St. Martin De Porres Hospital, Chiayi, 60069, Taiwan.
Yuan-Yen ChangDepartment of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, and Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrahydrocurcumin (THC), a major curcuminoid metabolite known for its antioxidant and anti-inflammatory properties, has potential for reducing brain inflammation. This study investigated THC's anti-inflammatory responses and molecular mechanisms against

Indexed as

CurcuminAnimalsCathepsin BCell LineHeme Oxygenase-1InflammasomesLipopolysaccharidesMAP Kinase Signaling SystemMembrane ProteinsMiceMicrogliaNLR Family, Pyrin Domain-Containing 3 Proteinp38 Mitogen-Activated Protein KinasesPseudomonas aeruginosaPyroptosisReactive Oxygen SpeciesCathepsin BCtsb protein, mouseCurcuminHeme Oxygenase-1Hmox1 protein, mouseInflammasomesLipopolysaccharidesMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousep38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciestetrahydrocurcuminBV-2 cellsinflammasomeNLRP3Pseudomonas aeruginosa LPS (P.a. LPS)pyroptosisTetrahydrocurcumin (THC)

Identifiers

PMID41049444
PMCPMC12492362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.