Evidence map›Paper›PMID 41049425›Full record

ArticleInternational journal of medical sciences2025

Targeting LC3B/MCL-1 expression by Protodioscin induces autophagy and apoptosis in human glioblastoma cells

Ching-Ting Tai, Yi-Hsien Hsieh, Hsiang-Lin Lee, Pei-Ni Chen, Hui-Ling Chiou, Tsai-Yun Wu, Chia-Liang Lin, Yi-Chen Lin, Chien-Min Chen

Abstract read
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In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ching-Ting TaiInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yi-Hsien HsiehInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hsiang-Lin LeeSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Pei-Ni ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hui-Ling ChiouSchool of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Tsai-Yun WuSchool of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Chia-Liang LinDepartment of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yi-Chen LinInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chien-Min ChenDivision of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protodioscin (PD), a natural steroidal saponin extracted from Dioscorea and Tribulus terrestris, has been shown to exhibit anticancer, antimetastatic, and pro-autophagic and apoptotic activities in various malignant tumor cells. However, its antitumor potential and molecular mechanisms in glioblastoma remain unclear. This study aimed to investigate the effects of PD on apoptosis and autophagy in human glioblastoma cells using both

Indexed as

Brain NeoplasmsDiosgeninGlioblastomaMicrotubule-Associated ProteinsMyeloid Cell Leukemia Sequence 1 ProteinSaponinsAnimalsApoptosisAutophagyCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceMice, NudeMolecular Docking SimulationDiosgeninMAP1LC3B protein, humanMCL1 protein, humanMicrotubule-Associated ProteinsMyeloid Cell Leukemia Sequence 1 ProteinSaponinsApoptosisAutophagyGlioblastomaLC3MCL-1Protodioscin

Identifiers

PMID41049425
PMCPMC12492353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.