ArticleNational science review2025
Ultrasensitive optoelectronic biosensor arrays based on twisted bilayer graphene superlattice.
Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Development and Application of SRCA for Rapid Detection of Pseudomonas aeruginosa in Bottled Drinking Water.Molecular biotechnology · 2026Article
- Electrochemical in-biosensing computing.National science review · 2026Article
- Reduced Graphene Oxide and Nickel Nanoparticle Nanocomposites: Tailoring the Nanoparticle Size for Enhanced Glucose Electrochemical Sensors.ACS omega · 2026Article
- Compressional strain-driven tuning of structural, optical, electronic, mechanical and thermodynamic attributes of double perovskite oxide BaLaSrBiOScientific reports · 2026Article
- Mechanochemically Synthesized Amidetriazoles for Effective Optical and Electrochemical Detection of Anions.The Journal of organic chemistry · 2026Article
- An AuNP-labeled triple-helix molecular switch for ultrasensitive, on-site detection of tetracycline in milk via fiber-optic localized surface plasmon resonance biosensing.Food chemistry: X · 2026Article
- Facile synthesis of BiRSC advances · 2026Article
- Advancements in nanobiosensors for early cancer detection, challenges, treatment, and future prospects: a comprehensive review.Discover nano · 2026Review
- Simultaneous electrochemical detection of imipenem and meropenem using a Pt-Au bimetallic nanoparticle-decorated 3D graphene oxide modified glassy carbon electrode.Scientific reports · 2026Article
- Recent Advances in Electrochemical Biosensors for the Detection of Milk Adulterants.Biosensors · 2026Review
- Comprehensive Review on DNA Hydrogels and DNA Origami-Enabled Wearable and Implantable Biosensors.Biosensors · 2025Review
- Exciton-plasmon coupling in tBLG-Au nanodisks for ultrasensitive miRNA sensing.National science review · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in twistronics have revealed tunable optoelectronic properties in twisted bilayer graphene (tBLG), including angle-dependent dielectric responses and enhanced light absorption due to van Hove singularity (VHS). However, achieving high photoresponsivity in tBLG-based sensors typically requires intense illumination. We present an ultrasensitive optoelectronic biosensor integrating tBLG superlattices with Au nanodisks and clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a via DNA origami. By aligning the 9.4° tBLG's VHS absorption spectrum with Au nanodisks' plasmonic resonance at 60 μW, we achieve a 7-fold photocurrent enhancement over pristine tBLG. CRISPR-Cas12a-mediated trans-cleavage dynamically modulates the local dielectric environment, enabling sub-femtomolar (44.63 attomolar, aM) nucleic acid detection without external amplification. Clinical validation using lung cancer samples shows high concordance with quantitative polymerase chain reaction (qPCR), demonstrating real-time, label-free detection of microRNA (miRNA). This hybrid platform combines moiré-engineered optoelectronics with programmable bio-nanoarrays, offering a scalable solution for precision diagnostics with ultralow detection limits and rapid response times.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.