Evidence map›Paper›PMID 41049401›Full record

ReviewOne health (Amsterdam, Netherlands)2025

A One Health framework to assess the economic returns on investment in livestock antimicrobial stewardship.

Alejandro Acosta, David Roland-Holst, Francesco Nicolli, Wondmagegn Tirkaso, Jozimo Santos Rocha, Junxia Song

Abstract readReview
In one paragraph

Review in One health (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Reframing livestock antimicrobial use as a global public good.One health (Amsterdam, Netherlands) · 2026
    Review
  3. Review
  4. Article
  5. LiveFrontiers in veterinary science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alejandro AcostaAnimal Production and Health Division, Food and Agriculture Organization of the United Nations, Rome, Italy.
David Roland-HolstDepartment of Agricultural and Resource Economics, University of California, Berkeley, USA.
Francesco NicolliAnimal Production and Health Division, Food and Agriculture Organization of the United Nations, Rome, Italy.
Wondmagegn TirkasoAnimal Production and Health Division, Food and Agriculture Organization of the United Nations, Rome, Italy.
Jozimo Santos RochaInvestment Centre, Food and Agriculture Organization of the United Nations, Rome, Italy.
Junxia SongAnimal Production and Health Division, Food and Agriculture Organization of the United Nations, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial use (AMU) in livestock plays a critical role in sustaining animal health and productivity, yet its overuse and misuse accelerates the emergence of antimicrobial resistance (AMR), posing systemic threats to public health, economic resilience, and global food security. While existing economic analyses have examined discrete sectoral impacts, they often overlook the complex interconnections between farm-level decision-making, governance structures, and broader macroeconomic dynamics. This perspective presents a One Health economic framework for evaluating the returns on investment (ROI) in livestock antimicrobial stewardship. Drawing on interdisciplinary literature from economics, public health, and veterinary science, we map the pathways through which policy environments, market incentives, and production systems shape AMU and influence its downstream economic consequences. By integrating microeconomic, governance, and macroeconomic perspectives, the framework offers a structured basis for evaluating trade-offs between short-term productivity gains and the longer-term costs of AMR, while identifying cross-sectoral synergies that strengthen public health and economic resilience. Designed for future application in computable general equilibrium (CGE) models, the framework offers a conceptual foundation for integrating antimicrobial stewardship into national development strategies within a One Health approach.

Indexed as

Antimicrobial ResistanceAntimicrobial UseLivestockOne HealthReturns on Investment

Identifiers

PMID41049401
PMCPMC12492032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.