Evidence map›Paper›PMID 41049395›Full record

ArticleClinical and translational radiation oncology2026

In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy.

Anna Kirstein, Dan Ionascu, Michael A S Lamba, Bianca M Ruffolo, Katherine J Crail, Anthony E Mascia, Mathieu G Sertorio, Benjamin H Hinrichs, Chad Zender, Maria A Lehn and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anna KirsteinCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Dan IonascuDepartment of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati OH 45219, USA.
Michael A S LambaDepartment of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati OH 45219, USA.
Bianca M RuffoloCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Katherine J CrailCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Anthony E MasciaCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Mathieu G SertorioDepartment of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati OH 45219, USA.
Benjamin H HinrichsDepartment of Pathology & Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.
Chad ZenderDepartment of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Cincinnati, OH 45219, USA.
Maria A LehnDepartment of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Trisha M Wise-DraperDepartment of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
John P PerentesisCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Yi ZhengCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Susanne I WellsCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Funding

ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
New activities of the human DEK oncogeneR01CA239605 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI WELLS, SUSANNE I · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA239605NIEHS NIH HHS T32 ES007250
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Head and Neck Squamous Cell Carcinoma (HNSCC)Proton therapyRadiationRelative biological effectiveness (RBE)X-ray radiation

Identifiers

PMID41049395
PMCPMC12492289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.