ArticleCerebral circulation - cognition and behavior2025
On the origin of cerebral small vessel disease: MRI markers of cSVD in young adults with hypertension.
Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Imaging markers of vascular cognitive impairment: Current advances and future directions.Cerebral circulation - cognition and behavior · 2026Article
- Tissue-specific diffusion abnormalities and localized free-water reductions in hypertension despite no detectable group difference in the DTI-ALPS index.Frontiers in medicine · 2026Article
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11 authors.
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Abstract
Introduction: Cerebral small vessel disease (cSVD) contributes to stroke and cognitive decline, with MRI markers of cSVD increasing with age. Hypertension is an important risk factor for cSVD in older adults but its impact in younger individuals remains less clear. This study investigates whether MRI markers of cSVD are more prevalent in young hypertensive individuals compared to normotensive controls. Methods: In this cross-sectional study, 60 patients with hypertension and 21 controls aged 18-55 years underwent 3T MRI to assess cSVD markers: white matter hyperintensities (WMH), lacunes, and microbleeds. Group differences were assessed using Results: Patients with hypertension were older (median (IQR) 35.6 (29.6-41.4) years vs 29.2 (27.8-33.2) years), had a higher BMI, and lower education levels while proportion of females was similar. Deep WMH burden was significantly higher in hypertensive participants (median Fazekas score: 1 [IQR: 0-1] vs 0 [IQR: 0-0]; Conclusion: WMH are more prevalent in young adults with hypertension, suggesting early microvascular brain changes. These findings underscore the importance of early detection and treatment of hypertension to potentially prevent long-term cerebrovascular changes.
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