Evidence map›Paper›PMID 41049312›Full record

ArticleClinical parkinsonism & related disorders2025

Changes in the olfactory tract of patients with early Parkinson's disease: A DTI tractography study.

Pasquale Nigro, Andrea Chiappiniello, Filippo Bucherini, Pietro Chiarini, Alessandro Mechelli, Carlo Maremmani, Federico Paolini Paoletti, Roberto Tarducci, Andrea Fiacca, Lucilla Parnetti and 1 more

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Article in Clinical parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Pasquale NigroMovement Disorders Center, Neurology Department, Perugia General Hospital and University Hospital of Perugia, Perugia, Italy.
Andrea ChiappinielloDepartment of Medical Physics, Perugia General Hospital, Perugia, Italy.
Filippo BucheriniDepartment of Medical Physics, Perugia General Hospital, Perugia, Italy.
Pietro ChiariniDepartment of Neuroradiology, Perugia General Hospital, Perugia, Italy.
Alessandro MechelliMovement Disorders Center, Neurology Department, Perugia General Hospital and University Hospital of Perugia, Perugia, Italy.
Carlo MaremmaniNeurology Unit, Ospedale Apuane, Azienda USL Toscana Nord Ovest, Massa, Italy.
Federico Paolini PaolettiNeurology Department, Perugia General Hospital and University Hospital of Perugia, Perugia, Italy.
Roberto TarducciDepartment of Medical Physics, Perugia General Hospital, Perugia, Italy.
Andrea FiaccaDepartment of Neuroradiology, Perugia General Hospital, Perugia, Italy.
Lucilla ParnettiNeurology Department, Perugia General Hospital and University Hospital of Perugia, Perugia, Italy.
Nicola TambascoMovement Disorders Center, Neurology Department, Perugia General Hospital and University Hospital of Perugia, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: olfactory impairment is a clinical feature of Parkinson's disease (PD) even in the early phases. Diffusion tensor imaging fiber tracking analysis (DTI-FTA) has been able to highlight changes in the olfactory tract in PD, however in early phases of PD this analysis has not been investigated. We investigated the olfactory tract by DTI-FTA in early stages of PD (ePD). Methods: All patients were assessed using the Italian Olfactory Identification Test (IOIT), the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III) and the Hoehn and Yahr (H&Y) scale. Diffusion imaging was conducted by 3 T MRI. Results: Overall, 26 PD patients and 20 healthy subject were recruited. Hyposmia was observed in all PD patients. DTI-FTA of the olfactory tract showed significant mean diffusivity (MD) increases and a tract volume decrease for PD group. MD and age, only in the PD group, were significant for multiple correlations. Conclusion: DTI-FTA identified microstructural changes in the olfactory tract even in hyposmic ePD patients.

Indexed as

Diffusion tensorHyposmiaMagnetic resonance imagingMRIOlfactionOlfactory tractParkinson’s diseaseTractography

Identifiers

PMID41049312
PMCPMC12489904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.