Evidence map›Paper›PMID 41049121›Full record

Observational studyInternational journal of public health2025

Assessing the Value of T cell Monitoring in the General Population of Children and Adolescents - Insights From the Ciao Corona Cohort Study.

Alessia Raineri, Sonja Rueegg, Thomas Radtke, Susi Kriemler, Kyra Zens, Giuseppe Pantaleo, Craig Fenwick, Céline Pellaton, Milo A Puhan

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessia RaineriEpidemiology, Biostatistics, Prevention Institute, University of Zurich, Zurich, Switzerland.
Sonja RueeggEpidemiology, Biostatistics, Prevention Institute, University of Zurich, Zurich, Switzerland.
Thomas RadtkeEpidemiology, Biostatistics, Prevention Institute, University of Zurich, Zurich, Switzerland.
Susi KriemlerEpidemiology, Biostatistics, Prevention Institute, University of Zurich, Zurich, Switzerland.
Kyra ZensEpidemiology, Biostatistics, Prevention Institute, University of Zurich, Zurich, Switzerland.
Giuseppe PantaleoDivision of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Craig FenwickDivision of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Céline PellatonDivision of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Milo A PuhanEpidemiology, Biostatistics, Prevention Institute, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Serological monitoring of SARS-CoV-2 antibodies in children and adolescents has been crucial for pandemic surveillance and response, while the role of T cell response monitoring remains uncertain. This study aimed to assess the potential of T cell response monitoring in children and adolescents during the COVID-19 pandemic. Methods: We compared antibody and T cell-mediated immune responses in a subpopulation (n = 109) of children and adolescents from the Ciao Corona cohort study. Participants were followed up over 6 months, from November/December 2021 to June/July 2022, during the Delta and Omicron waves in Switzerland. Results: Circulating, virus-specific T cell responses in children and adolescents were generally low and heterogeneous. T cell-mediated responses were not consistent with SARS-CoV-2 infection status, with responses detectable in some seronegative individuals and not detectable in a considerable number of seropositive participants. Conclusion: Circulating, virus-specific T cell responses to SARS-CoV-2 in children and adolescents from the general population offer limited additional insight. Monitoring humoral immunity is likely a more cost-effective approach and should be the primary focus of immunological surveillance in the general paediatric population.

Indexed as

Antibodies, ViralCOVID-19Immunologic SurveillanceSARS-CoV-2T-LymphocytesAdolescentChildFemaleFollow-Up StudiesHumansImmunity, CellularMaleProspective StudiesSeroepidemiologic StudiesSwitzerlandAntibodies, Viralcellular immunityCOVID-19humoral immunitySARS-CoV-2surveillance

Identifiers

PMID41049121
PMCPMC12489368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.