ArticleJournal of inflammation research2025
The Association Between Markers of Lipid Homeostasis, Inflammation, and Atherosclerosis Index in Patients with Type 2 Diabetes and Coronary Heart Disease Stratified by Glycemic Control: A Cross-Sectional Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Diagnostic value of systemic immune-inflammation composite index combined with triglyceride-glucose index in type 2 diabetes patients with coronary heart disease: a retrospective diagnostic model study.BMC cardiovascular disorders · 2026Article
- The Central Role of Lipid Metabolism Disorders in Diabetes Mellitus: Mechanisms, Clinical Manifestations, and Emerging Therapeutic Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Association of systemic inflammation response index and triglyceride-glucose index with the severity of coronary artery stenosis in elderly patients: a retrospective cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Phytochemicals Characterization and Antidiabetic Efficacy ofIranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This cross-sectional study investigates the relationship between systemic markers of lipid homeostasis, inflammation, and atherosclerosis index (AI) in patients with both type 2 diabetes and coronary heart disease (CHD), stratified by their glycemic control status. Methods: A total of 120 patients with type 2 diabetes and CHD were included and stratified into a Good Glycemic Control group (GGC, HbA1c<7%, n=72) and a Poor Glycemic Control group (PGC, HbA1c≥7%, n=48). AI was assessed using brachial-ankle pulse wave velocity (baPWV), and coronary stenosis was evaluated angiographically. Blood lipids, glucose metabolism indicators (Fasting Plasma Glucose [FPG], Fasting Insulin [FINS], HOMA-IR), and serum inflammatory markers (TNF-α, IL-1β, hs-CRP) were quantified. Pearson correlation and logistic regression analyses were used to assess associations and identify risk factors for AI. Results: The PGC group exhibited significantly higher AI and coronary stenosis scores, a more atherogenic lipid profile (higher TC, TG, LDL-C; lower HDL-C), and elevated HOMA-IR and inflammatory markers compared to the GGC group (all P<0.05). Baseline characteristics and medication use were similar, except for higher insulin use in the PGC group. Pearson analysis revealed that AI was positively correlated with hs-CRP, TG, coronary stenosis scores, and HOMA-IR (all P<0.05). Logistic regression identified hs-CRP, TG, coronary stenosis score, and HOMA-IR as independent risk factors for increased AI. Conclusion: In patients with type 2 diabetes and CHD, poor glycemic control is strongly associated with increased arterial stiffness, dyslipidemia, systemic inflammation, and insulin resistance. These findings highlight the critical, intertwined roles of these pathways in atherosclerosis and underscore the necessity of a multifactorial approach to cardiovascular risk management in this high-risk population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.