Evidence map›Paper›PMID 41049046›Full record

ArticleJournal of respiratory biology and translational medicine2025

Mitochondrial Lon Peptidase 1 Controls Diaphragm and Lung Development in a Context-Dependent Manner.

Le Xu, Chunting Tan, Nicole Talaba, Andrew Sou, Yufeng Shen, Wendy K Chung, David J McCulley, Xin Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of respiratory biology and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Le XuDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Chunting TanDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Nicole TalabaDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Andrew SouDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Yufeng ShenDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
David J McCulleyDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Xin SunDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Balancing Airway Progenitor versus Progeny: a Pathway from MitochondriaR01HL160019 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2021 to 2024
$2.1M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Frontiers at the edge: Subpleural fibroblasts orchestrate pulmonary fibrosis progressionK99HL171830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI XU, LE · 2024 to 2025
$306k
NHLBI NIH HHS K99 HL171830NHLBI NIH HHS R01 HL160019NIH HHS S10 OD026929NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Congenital Diaphragmatic Hernia (CDH) is a rare neonatal disorder causing diaphragmatic defects and cardiopulmonary hypoplasia, traditionally attributed to mechanical compression from organ herniation. However, emerging evidence suggests genetic mutations may independently impair lung development, prompting debate over CDH etiology. Here, we investigated the requirement of mitochondrial function guarded by LON peptidase 1 (

Indexed as

CDHDiaphragmFGF10LONP1LungMitochondriaSHH

Identifiers

PMID41049046
PMCPMC12490049

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.