ArticleFrontiers in medicine2025
The predictive value of serum MHR combined with classical metabolic syndrome components in the first trimester for gestational metabolic syndrome: a prospective cohort study in China.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The objective of the study was to investigate the relationship between inflammatory markers, the serum monocyte-to-high-density lipoprotein cholesterol ratio (MHR) in the first trimester, and gestational metabolic syndrome (GMS), and to identify the risk factors for GMS in early pregnancy and its predictive value. Methods: This prospective cohort study included 1,410 pregnant women at gestational ages of 7-12 weeks. Pregnant women underwent regular prenatal examinations. Basic information and clinical data of pregnant women were collected. Univariate analysis was performed to identify factors associated with GMS. Variables with a Results: Univariate analysis revealed that age, a history of adverse pregnancy outcomes (APOs), body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), white blood cell (WBC) counts, monocyte (MONO) levels, and the MHR in early pregnancy were associated with GMS ( Conclusion: This study has confirmed the predictive value of serum MHR combined with classical MS components in the first trimester for identifying GMS, which could lead to better and earlier identification of GMS patients and provide new ideas for early diagnosis and prevention of GMS.
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