Evidence map›Paper›PMID 41048966›Full record

ArticleFrontiers in medicine2025

RNA sequencing reveals transcriptional signatures of drug response and SARS-CoV-2 interaction in colorectal cancer cells.

Alaa K Hameed, Ifad K Abd Al-Shibly, Rana A Ghaleb

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Alaa K HameedDepartment of Laboratories, Al-Hussein Teaching Hospital, Al-Muthanna Health Department Employee, Al-Muthanna, Iraq.
Ifad K Abd Al-ShiblyDepartment of Microbiology, College of Medicine, Babylon University, Hilla, Iraq.
Rana A GhalebDepartment of Human Anatomy, College of Medicine, Babylon University, Hilla, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the molecular impact of cisplatin, Actemra (tocilizumab), remdesivir, and SARS-CoV-2 infection on colorectal cancer (CRC) SW-480 cells using RNA sequencing (RNA-Seq). Differential gene expression analysis revealed treatment-specific transcriptional changes. Cisplatin led to the downregulation of genes involved in lipid metabolism and focal adhesion, while remdesivir upregulated chromatin remodeling pathways. SARS-CoV-2 infection altered cytokine signaling, particularly IL-17 and TNF-

Indexed as

Actemracisplatincolorectal cancerremdesivirRNA sequencingSARS-CoV-2

Identifiers

PMID41048966
PMCPMC12488652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.