ArticleFrontiers in medicine2025
Atypical manifestation of psoriasis in the elderly: possible expression of Mal de Meleda diagnosis review and case report.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mal de Meleda (MDM) is a rare hereditary skin disorder classified as an autosomal recessive palmoplantar keratoderma, with an estimated prevalence of 1 in 100,000 individuals. It is commonly linked to consanguineous parentage and typically presents during early childhood. The hallmark features of the condition include transient thickening of the palms and soles, skin sclerosis and atrophy, scleroatrophic erythematous lesions, pseudoainhum formation around the digits, and erythema around the mouth. Due to its rarity, many dermatologists may lack clinical familiarity with MDM. Moreover, there is considerable phenotypic similarity between Mal de Meleda and other forms of palmoplantar keratoderma, as well as certain erythrokeratodermas, making clinical differentiation particularly difficult. Therefore, genetic testing to identify causative mutations plays a crucial role in confirming the diagnosis. Genetic alterations in the
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