ArticleFrontiers in medicine2025
A localized vertebral infection model of pyogenic spondylitis induced by
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background and purpose: Pyogenic spondylitis (PS) is clinically challenging and induces disastrous consequences for patients. The pathogenesis of PS is difficult to explore due to a lack of ideal animal models. Thus, we aimed to reproduce the local pathogenesis of PS in an innovative animal model induced by Methods: Rats were injected with planktonic Results: Our results revealed that infected rats experienced rapid weight loss, high fever, and significantly increased white blood cell count, interleukin 1β, and C-reactive protein (CRP) levels in the short term. Radiographic examination revealed bone damage in groups that received 2 × 10 Conclusions: This study provides an innovative PS animal model that simulates a local iatrogenic vertebral infection and develops innovative and effective strategies for its treatment, but does not simulate the hematogenous dissemination characteristics of most clinical cases of pyogenic spondylitis.
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