SynthesisFrontiers in psychiatry2025
Association of delirium with post-traumatic stress disorder: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Delirium, a prevalent form of acute brain dysfunction, is characterized by perceptual disturbances that may lead to the formation of delusional memories. This pathological process could subsequently elevate the risk of developing posttraumatic stress disorder (PTSD). However, the findings of previous research are inconsistent, and the association has not been systematically evaluated. Therefore, this study attempts to clarify the epidemiological relationship between delirium and PTSD as well as its clinical significance through a thorough integration of the available data, aiming to provide an evidence-based foundation for the early identification of high-risk patients and the creation of focused intervention strategies. Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines during the literature search. Comprehensive searches were conducted in PubMed, Ovid MEDLINE, APA PsycINFO, Embase, Scopus, and CINAHL, covering all relevant literature published from each database's inception until April 3, 2025. The search strategy combined free-text terms with controlled vocabulary (MeSH/Emtree terms) related to delirium and PTSD. This systematic review was registered with PROSPERO (CRD420251031880). Results: A total of 11 articles were included in this study. Meta-analysis of unadjusted ORs revealed that patients with delirium exhibited a significantly higher risk of developing PTSD compared to non-delirium controls (OR = 3.31, 95% CI [2.21-4.97]). After adjusting for potential confounders, the pooled results based on adjusted ORs continued to indicate a significant association between delirium and increased PTSD risk (OR = 3.96, 95% CI [1.85-8.50]). Six studies explored differences in PTSD scores between delirious and non-delirious patients. Of the four studies initially reporting median values, two were excluded following skewness assessment for non-normal data distribution. The data from the remaining two studies were transformed into mean ± Conclusion: This meta-analysis found a significant association between PTSD and delirium. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251031880, identifier CRD420251031880.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.