Evidence map›Paper›PMID 41048782›Full record

ReviewACS omega2025

Research Progress on Regulating Autophagy in Traditional Chinese Medicine for the Treatment of Traumatic Brain Injury.

Yan Cao, Hengxi Li, Hongyan Jiang, Xinyuan Luo, Aiping Yin, Jia Wu, Xiaobing Guo, Haiying Wu, Ping Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan CaoDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Hengxi LiDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Hongyan JiangDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Xinyuan LuoDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Aiping YinDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Jia WuDepartment of Experimental Teaching Center, Faculty of Basic Medicine Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Xiaobing GuoDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.
Haiying WuDepartment of Emergency and Intensive Care Unit, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan, China.
Ping LiDepartment of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, 650500 Kunming, Yunnan, China.ORCID https://orcid.org/0009-0002-8571-8523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI), characterized by structural brain damage caused by external physical shocks, is a significant global health challenge. Autophagy plays an important role in the cellular self-protection mechanism during its pathological progression. Traditional Chinese medicine (TCM) has a long history and unique advantages in neuroprotection. This review summarizes the key markers of autophagy and the relevant signaling pathways involved in autophagy in TBI, mainly including the PI3K/Akt/mTOR, AMPK/mTOR, Nrf2, TLR4 signaling pathways, and the endoplasmic reticulum stress autophagy axis. In addition, this paper summarizes the recent advances in TCM approaches in TBI autophagy treatment, such as terpenoids, flavonoids, polyphenols, alkaloids, and carotenoids, which are active components of TCM, as well as acupuncture nonpharmacological therapies.

Identifiers

PMID41048782
PMCPMC12489624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.