ArticleACS omega2025
Exploring Caffeine Extraction Using Hydrophobic Deep Eutectic Solvents: Experimental and Theoretical Approaches.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Recent Research Advances in the Application of Deep Eutectic Solvents for the Chemical Processes of the Nuclear Fuel Cycle.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrophobic deep eutectic solvents (HDESs) are emerging as sustainable, biodegradable, and nontoxic alternatives to traditional organic solvents in liquid-liquid extraction processes. This study investigates the use of HDESs, specifically eutectic mixtures of dl-menthol combined with acetic or hexanoic acids, for extracting caffeine from coffee beans (CB), coffee skin (CS), and guaraná drink (GD). Solvent screening using COSMO-RS modeling was performed to identify effective HDES systems. Caffeine detection employed UV/vis spectrophotometry at 274 nm (dl-menthol/acetic acid system) and 284 nm (dl-menthol/hexanoic acid system), with application of Gaussian fitting to minimize spectral interferences. The optimal extraction conditions were determined to be 65 °C and a 1:1 initial solution to solvent (L/L) ratio. Under these conditions, the dl-menthol/acetic acid solvent extracted 0.765 ± 0.007 mg of caffeine per 100 mg of coffee beans, outperforming the dl-menthol/hexanoic acid solvent, which extracted 0.610 ± 0.010 mg. Comparable results were observed for the other matrices, with 0.66 ± 0.01 mg caffeine per 400 mg of coffee skin and 0.57 ± 0.01 mg per 10 mL of guaraná drink. The method presented high precision, with a standard deviation of ±0.0826 mg L
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Registered trials
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