ArticleACS omega2025
Elucidating the Neuroprotective Mechanism of Geissoschizine Methyl Ether against Parkinson's Disease: Inhibition of Ferroptosis Pathway via Network Pharmacology and In Vitro Validation.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Geissoschizine methyl ether-(GME) is an indole alkaloid isolated from Uncariae Ramulus Cum Uncis, known for its various biological activities, including antioxidant effects, and neuroprotective properties. However, it has not yet been confirmed whether Geissoschizine methyl ether can protect dopaminergic neurons from death by inhibiting ferroptosis. In this study, First, network pharmacology is used to predict the action targets of GME in relation to Parkinson's disease and to perform pathway enrichment analysis. Molecular docking technology is then employed to further confirm the relevant action targets. Furthermore, we established a cell model using the ferroptosis inducers Erastin and MPP
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