ReviewACS omega2025
Aminic Organoselenium Compounds: Promising Antioxidant Agents.
Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Benzylamine-Based Organoselenium Compounds as Glutathione Peroxidase Mimics: Antioxidant and Antibacterial Agents.Chembiochem : a European journal of chemical biology · 2026Article
- Progress in the Synthesis of Organoselenium Compounds: Conventional Routes Versus Green Approaches.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant research interest has been devoted to organoselenium compounds due to their diverse biological activities, particularly their antioxidant properties, which mimic those of glutathione peroxidase (GPx) enzymes. While previous reviews have explored the broad spectrum of organoselenium chemistry and their applications, this review focuses specifically on aminic organoselenium compounds as next-generation GPx mimics and radical-trapping antioxidants. This work presents a comprehensive analysis of their catalytic mechanisms and structure-activity relationships (SAR) and the methodologies employed to evaluate their antioxidant efficacy. Unlike earlier reviews, this work emphasizes the critical role of aminic moieties in enhancing GPx-like activity and dual functionalities (peroxide decomposition and radical quenching). Key topics include the design principles of aminic organoselenium compounds, their performance relative to classical antioxidants like ebselen and α-tocopherol, and their promising use in developing treatments for conditions linked to oxidative stress. By consolidating advancements from the past two decades, this review connects existing research areas and suggests valuable pathways for future studies in developing multifunctional organoselenium antioxidants.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.