Evidence map›Paper›PMID 41048723›Full record

ArticleACS omega2025

Exploring Regioisomeric Indole-Furanone Tubulin Inhibitors.

Marcella Venettozzi, Taylor E Coburn, Blake A Evans, Merrelle S Grillo, Aivy N Le, Alex M Minayev, Ameer H Muse, Joed G Otchere, Keira L Potvin, Aidan P Staunton and 5 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marcella VenettozziDepartment of Biology, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Taylor E CoburnDepartment of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Blake A EvansDepartment of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Merrelle S GrilloDepartment of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Aivy N LeDepartment of Molecular Biology and Chemistry, Christopher Newport University, Newport News, Virginia 23606, United States.
Alex M MinayevDepartment of Molecular Biology and Chemistry, Christopher Newport University, Newport News, Virginia 23606, United States.
Ameer H MuseDepartment of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Joed G OtchereDepartment of Molecular Biology and Chemistry, Christopher Newport University, Newport News, Virginia 23606, United States.
Keira L PotvinDepartment of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Aidan P StauntonDepartment of Biology, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Charles M WatrobaDepartment of Biology, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Delaney M WilliamsDepartment of Biology, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Kathryn E ColeDepartment of Molecular Biology and Chemistry, Christopher Newport University, Newport News, Virginia 23606, United States.
Patricia MoweryDepartment of Biology, Hobart and William Smith Colleges, Geneva, New York 14456, United States.
Erin T PelkeyDepartment of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456, United States.ORCID https://orcid.org/0000-0001-8882-9128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tubulin is involved in microtubule function and affects mitosis, cell shape, migration, and the movement of organelles. Consequently, tubulin inhibitors have emerged as promising targets for cancer treatment. We previously identified a novel antitubulin motif that combines a furanone, indole, and electron-rich dimethoxyphenyl ring. The lead indole-furanone compound (

Identifiers

PMID41048723
PMCPMC12489669

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.