ArticleJournal of contemporary brachytherapy2025
Safety and efficacy of iridium-192 high-dose-rate interstitial brachytherapy for pleural and chest wall tumours: preliminary results.
Article in Journal of contemporary brachytherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Purpose: To evaluate the safety and efficacy of computed tomography (CT)-guided iridium-192 ( Material and methods: This single-centre retrospective cohort study involved 21 patients with pleural/chest wall malignant tumours treated between January 2024 and January 2025. All patients underwent HDR ISBT (30 Gy in a single fraction). Treatment included CT-guided needle implantation, three-dimensional dose optimisation (Oncentra system), and adherence to Radiation Therapy Oncology Group dose constraints for organs at risk (OARs). Efficacy endpoints included objective response (Response Evaluation Criteria in Solid Tumours v1.1), pain relief (Numerical Rating Scale), and dosimetric comparison with virtual stereotactic body radiotherapy. Safety was assessed using the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer toxicity criteria. Results: The median follow-up duration was 7.48 months. The objective response rate (complete response + partial response) was 76.19%, with 28.57% achieving a complete response and 47.62% achieving a partial response. Pain relief was achieved in 87.5% of patients with pretreatment pain, with numerical rating scale scores decreasing from moderate to severe (median, 6) to mild (median, 3) at 1 month. No ≥ grade II complications (e.g. bronchopleural fistula, pneumothorax) occurred; only four patients experienced minor subcutaneous haemorrhage/emphysema. Dosimetric analysis showed a significantly higher target mean dose with ISBT than with stereotactic body radiotherapy ( Conclusions: Computed tomography-guided
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