Evidence map›Paper›PMID 41048569›Full record

ArticleCytotechnology2025

Effects of mesenchymal stem cells derived from human exfoliated deciduous teeth (SHEDs) on airway inflammation in a murine model of acute asthma.

Shin Young Kim, Hyoung Kyu Yoon, Tai Joon An, Seo Hyun Kim, Yong Suk Jo, Joon Young Choi, Jung Hur, Chin Kook Rhee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shin Young KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-Gu, Seoul, 06591 South Korea.
Hyoung Kyu YoonDepartment of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Tai Joon AnDepartment of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Seo Hyun KimDepartment of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Yong Suk JoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-Gu, Seoul, 06591 South Korea.
Joon Young ChoiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Jung HurDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-Gu, Seoul, 06591 South Korea.
Chin Kook RheeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-Gu, Seoul, 06591 South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells from human exfoliated deciduous teeth (SHEDs) are self-renewing mesenchymal stem cells residing within the perivascular niche of the dental pulp. Previous studies have shown that SHEDs can attenuate acute lung injury and fibrosis. The effects of SEHDs on airway inflammation and airway hyperresponsiveness (AHR) were investigated in a mouse model of allergic asthma. In addition, clinical characteristics expected to respond well to SHED treatment were identified in co-culture experiments of peripheral blood mononuclear cells (PBMCs) and SHEDs from asthma patients. SHED treatment significantly decreased AHR, inflammatory cell counts in bronchoalveolar lavage fluid, and Th2 cytokine levels. In co-culture experiments using the patient's PBMCs and SHEDs, the levels of interleukin (IL)-4 in cultures from ex-smoker asthma patients decreased significantly, and the IL-4 level was shown to correlate with the patient's smoking history (pack-years). In mouse, SHED treatment decreased airway inflammation and AHR. In asthmatic patients with a history of smoking, IL-4 levels are significantly higher such that SHED treatment will be of particular benefit to this population. Nevertheless, given the small sample size and the absence of long-term follow-up, the findings should be interpreted with caution. Additional well-designed studies are warranted to validate these results.

Indexed as

AsthmaDental pulpEx-smokersInterleukin-4Stem cells

Identifiers

PMID41048569
PMCPMC12488544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.