Evidence map›Paper›PMID 41048561›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain.

Sachin Goyal, Ian Adams, Marena Montera, Nesia A Zurek, Shivali Goyal, Adinarayana Kunamneni, Karin N Westlund, Sascha R A Alles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sachin GoyalDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.
Ian AdamsDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.
Marena MonteraDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.
Nesia A ZurekDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.
Shivali GoyalDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.
Adinarayana KunamneniDepartment of Internal Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.
Karin N WestlundDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.
Sascha R A AllesDepartment of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an ATP-gated ion channel, is upregulated in sensory neurons and glial cells following nerve injury and is pivotal in chronic pain pathogenesis. This study evaluates the therapeutic potential of a novel humanized single-chain variable fragment antibody (hP2X4R scFv) targeting P2X4R in male mice models of neuropathic pain. Using spared nerve injury (SNI) and foramen rotundum inflammatory compression of the trigeminal infraorbital nerve (FRICT-ION) models, we demonstrate that a single intraperitoneal dose of hP2X4R scFv significantly reverses mechanical hypersensitivity for up to four weeks. Electrophysiological recordings from FosTRAP mice revealed that hP2X4R scFv reduced the excitability of Fos+ neurons in the spinal dorsal horn and ventrolateral periaqueductal gray (vlPAG), key regions involved in pain processing.

Identifiers

PMID41048561
PMCPMC12489909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.