Evidence map›Paper›PMID 41048559›Full record

ArticleJournal of Alzheimer's disease reports

A surgical therapy for Alzheimer's disease with lymphaticovenular anastomosis.

Xiwen Ma, Feiyun Wang, Guiqing Wang, Meiying Zhao, Youmao Zheng, Yintao Guo, Jingheng Wu, Yuntao Liu, Yulin Liu, Guinv He and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Xiwen MaDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0003-9086-838X
Feiyun WangDepartment of Microsurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0006-5412-000X
Guiqing WangDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Meiying ZhaoDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Youmao ZhengCenter for Plastic & Reconstructive Surgery, Department of Lymphatic Surgery & Reconstructive Microsurgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yintao GuoDepartment of Microsurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0009-5110-7215
Jingheng WuZhengzhou Branch of Beijing Jishuitan Hospital, Zhengzhou, China.
Yuntao LiuDepartment of Microsurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0001-0887-2538
Yulin LiuDepartment of Microsurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0000-7933-0915
Guinv HeDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Lixuan RenInstitute of Trauma and Metabolism, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0003-8825-9577
Zhenping GongDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Jingxin WangDepartment of Rehabilitation, Clinical Laboratory, Department of Anesthesia, Department of Nuclear Medicine, Imaging Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Li ChenDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Shoukui HuDepartment of Rehabilitation, Clinical Laboratory, Department of Anesthesia, Department of Nuclear Medicine, Imaging Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Qinjun ChuDepartment of Rehabilitation, Clinical Laboratory, Department of Anesthesia, Department of Nuclear Medicine, Imaging Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Zhengkai LiDepartment of Rehabilitation, Clinical Laboratory, Department of Anesthesia, Department of Nuclear Medicine, Imaging Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Jing WuDepartment of Rehabilitation, Clinical Laboratory, Department of Anesthesia, Department of Nuclear Medicine, Imaging Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Runtao LiDepartment of Rehabilitation, Clinical Laboratory, Department of Anesthesia, Department of Nuclear Medicine, Imaging Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0000-3088-6453
Xiaojie ZhangDepartment of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0002-3988-1901
Qian ShiDepartment of Microsurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0003-3128-4202
Hongkai LianInstitute of Trauma and Metabolism, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0001-6877-1037
Jianping YeInstitute of Trauma and Metabolism, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0003-3875-365X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Deep cervical lymphaticovenular anastomosis (dcLVA) surgery is able to control aging-associated Alzheimer's disease in patients. However, the efficacy rate remains unknown. Objective: This study is designed to test the surgery efficacy in the treatment of mild-to-moderate AD patients. Methods: This is a single-center retrospective study of dcLVA treatment of mild-to-moderate AD for 3 months. A total of 41 patients received the surgery, in which lymph vessels and lymph nodes in the district III of cervical area were identified using indocyanine fluorescence dye. The afferent lymphatics of the obstructed lymph nodes were connected to the jugular vein to fix the lymphatic blockage under a fluorescent microscope. The efficacy rate was examined at 3-month post-surgery by clinical scores and biomarkers. Results: Lymph flow obstruction was observed on both sides of cervical area in the AD patients. The obstruction was successfully resolved through the surgery, and AD progression was attenuated or even reversed in the patients according to improvement in the scales of MMSE, ADL, NPI, CDR-SB, and CGI-EI. The average effectiveness rate was 50% by the CDR-SB score improvement. The efficacy was higher with shorter disease duration but not influenced by age and Conclusions: The data demonstrate that dcLVA surgery is an effective and safe therapy for AD in mild-to-moderate patients with 50% efficacy rate as measured by improvement of the CDR-SB score.

Indexed as

Alzheimer's diseasedeep cervical lymphaticovenular anastomosislymphatic systemlymph nodesurgical therapy

Identifiers

PMID41048559
PMCPMC12495200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.