ArticleFrontiers in microbiology2025
The effect of cCMP and cUMP on growth of
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The aim of this study was to screen for possible biological effects of the non-canonical nucleotides 3',5'-cyclic uridine monophosphate (cUMP) and 3',5'-cyclic cytidine monophosphate (cCMP) on Pseudomonas aeruginosa beyond the already reported function in the bacterial pyrimidine cyclase system for antiphage resistance (Pycsar). Since endogenously synthesized cCMP was detected in growing bacterial cultures and the cCMP concentration was higher when nutrients became more restricted, we hypothesized that a membrane-permeable analog of cCMP added to growing cultures alters growth kinetics. Indeed, when growing in a nutrient-scarce minimum salt medium, the cCMP analog acetoxymethyl-cCMP led to a dose-dependent growth lag, whereas neither its native counterpart nor cAMP, cGMP, or cUMP induced such a lag. This inhibitory effect on growth translated into a sensitizing effect against the antibacterial drugs azithromycin and, very pronounced, against gentamicin. Since
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