Evidence map›Paper›PMID 41048445›Full record

ArticleBMJ neurology open2025

Gender differences in depression, anxiety, and quality of life in Parkinson's disease before and after deep brain stimulation surgery: a multicentre cohort study.

Molly G Abbott, Arteen Ahmed, Nicola Pavese, Antonella Macerollo, Edward J Newman, Jibril Osman Farah, Nagaraja Sarangmat, Anjum Misbahuddin, David Ledingham, Michelle GIbbs and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ neurology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Molly G AbbottKing's College London Institute of Psychiatry Psychology & Neuroscience, London, UK.ORCID https://orcid.org/0009-0009-8072-7018
Arteen AhmedKing's College London Institute of Psychiatry Psychology & Neuroscience, London, UK.ORCID https://orcid.org/0009-0005-9555-8721
Nicola PaveseNewcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Antonella MacerolloThe Walton Centre NHS Foundation Trust, Liverpool, UK.
Edward J NewmanNeurology, Queen Elizabeth University Hospital, Glasgow, UK.ORCID https://orcid.org/0000-0002-4456-7389
Jibril Osman FarahThe Walton Centre NHS Foundation Trust, Liverpool, UK.
Nagaraja SarangmatOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Anjum MisbahuddinBarking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.
David LedinghamNewcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Michelle GIbbsNewcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Russell MillsNewcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Keyoumars AshkanKing's College London Institute of Psychiatry Psychology & Neuroscience, London, UK.
Monty SilverdaleSalford Royal NHS Trust, Salford, UK.
Michael SamuelKing's College London Institute of Psychiatry Psychology & Neuroscience, London, UK.
David OkaiKing's College London Institute of Psychiatry Psychology & Neuroscience, London, UK.
Paul ShotboltKing's College London Institute of Psychiatry Psychology & Neuroscience, London, UK.ORCID https://orcid.org/0000-0001-8868-837X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Disproportionately fewer females with Parkinson's disease (PD) undergo deep brain stimulation surgery (DBS). Some data show worse depression, anxiety, and quality of life (QOL) in females with PD. Investigations into these gender disparities, or the effect of DBS on these non-motor symptoms, remain limited. Methods: 61 PD patients across seven UK DBS centres were recruited for the Clinical Response of Impulsive behaviours to deep brain Stimulation in PD (CRISP) prospective cohort study. Questionnaires measured primary outcomes of depression (Patient Health Questionnaire-9), anxiety (Generalised Anxiety Disorder-7) and QOL (Parkinson's Disease Questionnaire-39) before and 6 months after bilateral subthalamic nucleus DBS, and secondary outcomes of predictors of postoperative changes in mood. Results: Females were disproportionately under-referred for DBS (28% of cohort). Baseline depression and anxiety were similar between genders. While DBS significantly improved overall anxiety (p<0.001), females reported significantly more postoperative anxiety than males (median score 7 vs 1.5 Conclusions: DBS showed clinical efficacy for non-motor PD symptoms across genders, evidencing the need to close the gender gap in DBS. Analysis by gender highlighted significant disparities and postoperative predictors that provide impetus for tailored DBS counselling.

Indexed as

DEPRESSIONNEUROSURGERYPARKINSON'S DISEASE

Identifiers

PMID41048445
PMCPMC12496053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.