Evidence map›Paper›PMID 41048402›Full record

ArticleSoftwareX2025

HistomicsTK: A Python toolkit for pathology image analysis algorithms.

Fattaneh Pourakpour, Ákos Szölgyén, Ramin Nateghi, David A Gutman, David Manthey, Lee Ad Cooper

Abstract read
In one paragraph

Article in SoftwareX, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Histolytics: A panoptic spatial analysis framework for interpretable histopathology.Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fattaneh PourakpourDepartment of Electrical Engineering, McCormick School of Engineering, Northwestern University, USA.ORCID 0009-0009-5049-9704
Ákos SzölgyénDepartment of Pathology, Feinberg School of Medicine, Northwestern University, USA.
Ramin NateghiDepartment of Urology, Feinberg School of Medicine, Northwestern University, USA.
David A GutmanDepartment of Pathology, Emory School of Medicine, Emory University, USA.
David MantheyKitware, Inc., USA.
Lee Ad CooperDepartment of Pathology, Feinberg School of Medicine, Northwestern University, USA.

Funding

Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A., HUSSAIN, MAHA H · 2015 to 2025
$19.9M
The Neuropathologic Landscape of Alzheimer's Disease in Hispanic DecedentsR01AG062517 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany Nicole Dugger · 2019 to 2026
$10.5M
Project 3: AI Digital Pathology Tools to Address Disparities in Lymphoma Diagnosis and Classification for Underserved CommunitiesU54CA302435 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTOPHER R FLOWERS, JEAN L KOFF · 2025 to 2026
$7.4M
Brain Digital Slide Archive: An Open Source Platform for data sharing and analysis of digital neuropathologyU24NS133949 · NINDS · EMORY UNIVERSITY · PI Lee Cooper, Brittany Nicole Dugger · 2023 to 2026
$4.3M
Advanced Development of an Open-source Platform for Web-based Integrative Digital Image Analysis in CancerU24CA194362 · NCI · EMORY UNIVERSITY · PI COOPER, LEE, GUTMAN, DAVID ANDREW · 2015 to 2019
$3.6M
Guiding humans to create better labeled datasets for machine learning in biomedical researchR01LM013523 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COOPER, LEE, ENQUOBAHRIE, ANDINET ASMAMAW · 2021 to 2024
$2.3M
Informatics Tools for Quantitative Digital Pathology Profiling and Integrated Prognostic ModelingU01CA220401 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COOPER, LEE, FLOWERS, CHRISTOPHER R · 2018 to 2021
$1.3M
NCI NIH HHS P50 CA180995NCI NIH HHS U01 CA220401NCI NIH HHS U24 CA194362NCI NIH HHS U54 CA302435NIA NIH HHS R01 AG062517NINDS NIH HHS U24 NS133949NLM NIH HHS R01 LM013523
6 · The paper itself

Abstract

Growth in the digital imaging of glass tissue slides has produced petabytes of data, however, this data remains underutilized in biomedical research due in part to a lack of open-source software. HistomicsTK is an open-source Python package that provides preprocessing, segmentation, and feature extraction capabilities for building histology image processing pipelines. HistomicsTK can function as a standalone Python package or serve containerized pipelines through a web-based interface using the Digital Slide Archive platform. This paper provides an overview of HistomicsTK with illustrative use cases and describes how this project engages the community in software development and maintenance.

Indexed as

Digital pathologyImage analysisMedical imagingMicroscopyPathology

Identifiers

PMID41048402
PMCPMC12494233

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.