ArticleAesthetic surgery journal. Open forum2025
Epidermal and Dermal Regeneration Through Sequential Monopolar and Bipolar Radiofrequency: Evidence From an Aging Mouse Model.
Article in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Dual-mode Sequential Radiofrequency in Challenging Skin Types: Case Reports in Atopic-prone and Previously Treated Patients.Plastic and reconstructive surgery. Global open · 2026Article
- Sequential Monopolar-Bipolar Pulsed Radiofrequency for Non-Invasive Periorbital Rejuvenation: A Case Series.Clinical, cosmetic and investigational dermatology · 2026Article
- Clinical Evaluation of a Novel Dual-Mode Radiofrequency Device for Facial Laxity: A Case Series.Clinical, cosmetic and investigational dermatology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: It is well established that the aging process triggers various physiological changes, which may manifest as loss of hydration and the degradation of collagen and elastin fibers, ultimately leading to lines, wrinkles, and skin laxity. To restore the skin's youthful appearance, both noninvasive and minimally invasive procedures have been developed. Objectives: The authors of this study aim to evaluate the safety and efficacy of noninvasive monopolar vs sequential monopolar-bipolar radiofrequency (RF) irradiation from a single tip on skin quality in an aged mouse model. Methods: The experiment involved male mice aged 4 and 12 months. The Density RF device (Jeisys Global, Seoul, South Korea) used for irradiation employs both monopolar (Classic-Tip) and monopolar-bipolar (High-Tip) RF, operating at a frequency of 6.78 MHz. The device features an automatic impedance matching system that measures impedance in real time and determines the corresponding compensation value. RF irradiation was performed after applying coupling fluid to the dorsal skin of mice (4 cm Results: The RF-irradiated group has shown a significant increase in skin hydration and elasticity. The aging control group showed a 1.7-fold reduction in epidermal thickness compared with the young control group. However, in comparison with the aging control group, after 28 days, the RF irradiation group showed a substantially thicker epidermis, up to 1.5-fold thicker (monopolar group: 15.797 ± 1.093 µm, monopolar-bipolar group: 15.600 ± 0.963 µm). The monopolar group showed a 1.8-fold ( Conclusions: The sequentially monopolar-bipolar RF irradiation (Density High-Tip) system significantly increases epidermal thickness, collagen, and elastin fiber production and promotes fibroblast cell differentiation compared with the monopolar RF alone. Level of Evidence 4 Therapeutic:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.