ReviewInternational journal of nanomedicine2025
Silicon-Based Nanomaterials in Chronic Wound Healing: Mechanisms, Therapeutic Applications, and Clinical Prospects.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Smart Mesoporous Silica Nanoparticle-Based Drug Delivery Systems: Recent Advances in Biomedical Applications, Wound Healing and Therapeutic Perspectives.Pharmaceutics · 2026Review
- Mesoporous bioactive glass hybrid nanoparticles accelerate tendon-bone healing via synergistic angiogenesis and immunomodulation.Materials today. Bio · 2026Article
- Applications of Nanomaterials in Chronic Wound Healing and Scar Prevention.International journal of nanomedicine · 2026Review
- Thermosensitive in situ Hydrogel Based on Benzalkonium Chloride-Loaded Selenium-Doped Mesoporous Silica Nanoparticles for Diabetic Chronic Wound Treatment.International journal of nanomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silicon-based nanosystems are emerging as promising nanotherapeutic platforms in the biomedical field, particularly for the treatment of chronic wounds. These materials possess several advantageous features. They offer excellent drug-loading capacity, controlled and stimuli-responsive drug release, and highly customizable structures and functions. These characteristics make them well-suited for personalized therapeutic approaches.This review provides a comprehensive summary of recent advances in the application of silicon-based nanosystems in wound healing. It highlights their mechanisms of action and discusses future development directions. We begin by outlining the clinical significance and complex pathophysiological characteristics of chronic wounds. A detailed classification of silicon-based nanomaterials is then provided, including mesoporous silica nanoparticles and silicon-based composites. The review emphasizes their key roles in modulating inflammation, reducing oxidative stress, and promoting angiogenesis and tissue regeneration. In addition, we summarize recent findings from in vitro and in vivo studies, as well as updates from relevant clinical research. The biocompatibility and safety profiles of these systems are also comprehensively evaluated. Future research should focus on optimizing the synthesis of these materials and improving their long-term biosafety. Efforts should also aim to integrate multifunctional therapeutic strategies to enhance efficacy and translational potential. Moreover, large-scale, rigorously designed clinical trials are urgently needed. These studies will help build robust clinical evidence and support the practical application of silicon-based nanosystems in advanced wound care. In conclusion, silicon-based nanosystems represent a next-generation approach for wound therapy. However, further interdisciplinary research is essential to fully realize their clinical value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.