ArticleInternational journal of women's health2025
HPV Infection in Women with ASC-US in Eastern Marmara, Türkiye: Genotype Prevalence and Clinical Implications.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to retrospectively evaluate the distribution of human papillomavirus (HPV) genotypes, age-specific prevalence, and their association with histopathological outcomes in women with cervical cytology results reported as atypical squamous cells of undetermined significance (ASC-US) and concurrent high-risk HPV (hr-HPV) positivity. Patients and Methods: Among 39,189 records screened between October 2019 and October 2024, 705 patients with ASC-US and hr-HPV positivity were included. HPV genotyping was performed using real-time PCR, cytological evaluation followed the Bethesda System, and colposcopic biopsies were classified according to the Lower Anogenital Squamous Terminology (LAST) guidelines. Results: HPV-16 (25.6%), HPV-51 (7%), and HPV-31 (6.5%) were the most prevalent genotypes, detected in 28.2% (n=199) of hr-HPV-positive cases. HPV-16 demonstrated the strongest association with high-grade lesions, accounting for 47.6% of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Multiple HPV infections correlated with an elevated risk of CIN2+. Age-stratified analysis revealed HPV-16 predominance in women aged 40-49 years, whereas HPV-51 was more frequent in those ≥60 years. Conclusion: In ASC-US cases, HPV-16 is the predominant genotype and a significant predictor of high-grade cervical lesions. The unexpectedly high prevalence of HPV-51 and HPV-31 in this Turkish cohort underscores the importance of tailoring screening algorithms to regional genotype distributions. Furthermore, the observed age-specific variations in genotype prevalence highlight the need for age-adjusted management strategies.
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