ArticleFrontiers in public health2025
Hemoglobin-to-red blood cell distribution width ratio in the relationship between occupational aluminum exposure and cognitive function impairment: a mediation analysis.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the partial mediating role of the inflammatory marker hemoglobin-to-red cell distribution width ratio (HRR) in the association between occupational aluminum exposure and cognitive function impairment, and its significance. Methods: In this study, 401 workers from a Shanxi aluminum plant were selected by Cluster Sampling. Fasting elbow venous blood was collected for measuring routine blood counts, plasma aluminum concentration (P-Al) was measured using inductively coupled plasma mass spectrometry (ICP-MS), Montreal Cognitive Assessment (MoCA) was used to assess the cognitive function. Multiple linear regression was used to analyze the relationship between P-Al and cognitive function and HRR, and a restricted cubic spline model was used to fit the dose-response relationship, and mediated effects analysis was performed. Results: The median plasma aluminum concentration ( Conclusion: Occupational aluminum exposure negatively affects workers' cognitive function and HRR levels. HRR can partially explain the effects of occupational aluminum exposure on workers' cognitive function.
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