Evidence map›Paper›PMID 41048177›Full record

ArticleeLife2025

Unlocking the longevity code with stress.

Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle

Abstract readEditorial
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Loren CoccioloneDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, United States.ORCID https://orcid.org/0009-0003-7284-4886
Valeria UvarovaDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, United States.ORCID https://orcid.org/0009-0004-3788-3668
Patricija van Oosten-HawleDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, United States.ORCID https://orcid.org/0000-0002-5713-6457

Funding

Gut stress-induced intercellular signaling networks promoting longevity and proteostasisR01AG082970 · NIA · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI Patricija van Oosten-Hawle · 2023 to 2026
$1.5M
NIA NIH HHS R01 AG082970
6 · The paper itself

Abstract

Manipulating the neuronal pathway responsible for the hypoxic stress response in the worm

Indexed as

Caenorhabditis elegansLongevityStress, PhysiologicalAnimalsCaenorhabditis elegans ProteinsCaenorhabditis elegans ProteinsagingC. elegansFMO-2geneticsgenomicsHIF-1hypoxic stress responseneuroscienceTYRA-3

Identifiers

PMID41048177
PMCPMC12500308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.