Evidence map›Paper›PMID 41048141›Full record

SynthesisIranian biomedical journal2025

Transdermal Iontophoresis Insulin in Laboratory Animals: A Systematic Review.

Zeinab Ahmadpour Emshi, Mohammad Mohsen Roostayi, Aliyeh Daryabor, Sedigheh Sadat Naimi, Maryam Niajalili

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Iranian biomedical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeinab Ahmadpour EmshiStudent Research Committee, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Mohsen RoostayiPhysiotherapy Research Center, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti Medical University, Tehran, Iran.
Aliyeh DaryaborPhysiotherapy Research Center, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti Medical University, Tehran, Iran.
Sedigheh Sadat NaimiPhysiotherapy Research Center, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti Medical University, Tehran, Iran.
Maryam NiajaliliStudent Research Committee, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin therapy is essential for regulating glucose levels in diabetic patients. However, subcutaneous insulin injection, despite being a standard procedure, is invasive and often painful and can lead to complications such as skin damage and infections. These issues often result in poor patient compliance and inadequate glycemic control. Recently, transdermal insulin administration has been explored as an alternative to subcutaneous methods; however, no universally accepted protocol has been developed for its use. This systematic review aimed to evaluate the effect of iontophoresis on transdermal insulin administration in laboratory animals. Using the PICO search strategy and in accordance with PRISMA guidelines, relevant articles published from January 1980 to May 2025 were retrieved from Scopus, PubMed, ISI Web of Science, PEDro, Science Direct, and Google Scholar databases. The findings from these studies suggest that combining iontophoresis with physical enhancers of skin penetration can effectively regulate blood glucose levels while minimizing the risk of hypoglycemia.

Indexed as

InsulinIontophoresisAdministration, CutaneousAnimalsAnimals, LaboratoryBlood GlucoseBlood GlucoseInsulinDiabetes mellitusLaboratory animalsSkin

Identifiers

PMID41048141
PMCPMC12584341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.