ReviewJournal of neurochemistry2025
Tiny Messengers, Huge Consequences: Extracellular Vesicles and mTOR Signaling in Neuroinflammation.
Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tiny Messengers, Huge Consequences: Extracellular Vesicles and mTOR Signaling in Neuroinflammation.Journal of neurochemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Neuroinflammation plays a fundamental role in the pathogenesis of neurodegenerative disorders. Among the central regulators of this process are the mechanistic target of rapamycin (mTOR) signaling pathway and extracellular vesicles (EVs). This review discusses the bidirectional interaction between mTOR and EVs, describing their interconnection in the regulation of cellular communication and inflammatory responses in the central nervous system (CNS). On one hand, mTOR controls EV biogenesis and cargo composition, and, on the other hand, EVs also modulate mTOR activity in target cells with effects in neuronal survival, glial activation, and immune signaling. This bidirectional communication creates a feedback loop that, depending on cell context and molecular cues, may either promote neuroprotection or exacerbate neurotoxicity and inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.