Evidence map›Paper›PMID 41048107›Full record

ArticleOncotarget2025

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response.

Kyle R Cron, Ping Fang, Oanh Pham, Julie Janes, John Brandenburg, William Lu, Jonathan Zhu, Bret Peterson, Sara Tribble, Haixing Kehoe and 8 more

Abstract read
In one paragraph

Article in Oncotarget, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The renaissance ofFrontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kyle R CronActym Therapeutics, Berkeley, CA 94710, USA.
Ping FangActym Therapeutics, Berkeley, CA 94710, USA.
Oanh PhamActym Therapeutics, Berkeley, CA 94710, USA.
Julie JanesActym Therapeutics, Berkeley, CA 94710, USA.
John BrandenburgActym Therapeutics, Berkeley, CA 94710, USA.
William LuActym Therapeutics, Berkeley, CA 94710, USA.
Jonathan ZhuActym Therapeutics, Berkeley, CA 94710, USA.
Bret PetersonActym Therapeutics, Berkeley, CA 94710, USA.
Sara TribbleActym Therapeutics, Berkeley, CA 94710, USA.
Haixing KehoeActym Therapeutics, Berkeley, CA 94710, USA.
Anastasia MakarovaActym Therapeutics, Berkeley, CA 94710, USA.
Alex IannelloActym Therapeutics, Berkeley, CA 94710, USA.
Jean ChanActym Therapeutics, Berkeley, CA 94710, USA.
Justin SkobleActym Therapeutics, Berkeley, CA 94710, USA.
Hailey HeActym Therapeutics, Berkeley, CA 94710, USA.
Chris RaeActym Therapeutics, Berkeley, CA 94710, USA.
Christopher D ThanosActym Therapeutics, Berkeley, CA 94710, USA.
Akshata R UdyavarActym Therapeutics, Berkeley, CA 94710, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STACT is a modular, genetically engineered live attenuated

Indexed as

ImmunotherapyInterleukin-15Interleukin-15 Receptor alpha SubunitMembrane ProteinsNeoplasmsTumor MicroenvironmentAdaptive ImmunityAnimalsCell Line, TumorFemaleHumansImmunity, InnateMiceMice, Inbred C57BLInterleukin-15Interleukin-15 Receptor alpha SubunitMembrane Proteinsbacterial vectorIL-15myeloid cellsSTINGtumor microenvironment

Identifiers

PMID41048107
PMCPMC12758031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.